ire1 activator ixa4 (MedChemExpress)
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MedChemExpress
ire1 activator ixa4
Ire1 Activator Ixa4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ire1 activator ixa4/product/MedChemExpress
Average 94 stars, based on 12 article reviews
Ire1 Activator Ixa4, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 12 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ire1 activator ixa4/product/MedChemExpress
Average 94 stars, based on 12 article reviews
ire1 activator ixa4 - by Bioz Stars,
2026-02
94/100 stars
Images
1) Product Images from "BvrR From Brucella abortus Induces Neuroinflammation Through IRE1‐Mediated Activation of ATF2 and NF‐κB"
Article Title: BvrR From Brucella abortus Induces Neuroinflammation Through IRE1‐Mediated Activation of ATF2 and NF‐κB
Journal: MicrobiologyOpen
doi: 10.1002/mbo3.70219
Figure Legend Snippet: Effect of Brucella BvrR protein on IRE1 activation and ER morphology in HMC3 cells. (A) Western blot analysis of BvrR‐His protein expression. (B) Western blot analysis of BvfA‐His protein expression. (C) Subcellular localization of BvrR‐His and ER in HMC3 cells observed by laser confocal microscopy. (D) Transmission electron microscopy analysis of ER morphology in HMC3 cells from each group. (E) Western blot analysis of p‐IRE1 protein levels. (F) Quantification of p‐IRE1 protein levels normalized to GAPDH. Data are presented as means ± standard deviations from three independent replicates; * p < 0.05 versus Control; # p < 0.05 versus pcDNA3.1; & p < 0.05 versus BvfA‐His.
Techniques Used: Activation Assay, Western Blot, Expressing, Confocal Microscopy, Transmission Assay, Electron Microscopy, Control
Figure Legend Snippet: Brucella BvrR activates ATF2/IL‐6 and NF‐κB p65/TNF‐α signaling via IRE1. (A) Transmission electron microscopy analysis of ER morphology in HMC3 cells. (B) Western blot analysis of p‐IRE1, p‐ATF2, p‐p65, IL‐6, and TNF‐α protein levels. (C–G) Quantification of p‐IRE1, p‐ATF2, p‐p65, IL‐6, and TNF‐α expression normalized to GAPDH. Data are presented as means ± standard deviations from at least three independent experiments; * p < 0.05 versus Control; # p < 0.05 versus IXA4; & p < 0.05 versus GSK2850163; ! p < 0.05 versus BvrR.
Techniques Used: Transmission Assay, Electron Microscopy, Western Blot, Expressing, Control
Figure Legend Snippet: Effect of BvrR, IXA4, and GSK2850163 on IL‐6 and TNF expression. (A) ELISA measurement of IL‐6 in supernatants. (B) ELISA measurement of TNF‐α in supernatants. (C) RT‐qPCR analysis of IL6 mRNA expression. (D) RT‐qPCR analysis of TNF mRNA expression. Each assay was performed in six replicates, and data are presented as means ± standard deviations; * p < 0.05, ** p < 0.01 versus Control; # p < 0.05, ## p < 0.01 versus IXA4; & p < 0.05, && p < 0.01 versus GSK2850163; ! p < 0.05, !! p < 0.01 versus BvrR.
Techniques Used: Expressing, Enzyme-linked Immunosorbent Assay, Quantitative RT-PCR, Control
Figure Legend Snippet: Brucella BvrR activates IRE1, ATF2, and NF‐κB p65 in hippocampal microglia. (A) Immunofluorescence co‐localization of IBA‐1 and p‐IRE1. (B) Quantification of p‐IRE1 co‐localization with IBA‐1. (C) Immunofluorescence co‐localization of IBA‐1 and p‐ATF2. (D) Quantification of p‐ATF2 co‐localization with IBA‐1. (E) Immunofluorescence co‐localization of IBA‐1 and p‐p65. (F) Quantification of p‐p65 co‐localization with IBA‐1. (G) Western blot analysis of IL‐6 and TNF‐α protein levels in hippocampal tissue. (H) Quantification of IL‐6 expression normalized to GAPDH. (I) Quantification of TNF‐α expression normalized to GAPDH. Data are presented as means ± standard deviations from three independent experiments; * p < 0.05, ** p < 0.01 versus AAV‐ bvrR .
Techniques Used: Immunofluorescence, Western Blot, Expressing